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Article

Exploration of the causal relationship between inflammatory cytokines and type 2 diabetes via mendelian randomization and polygenic score.

Frontiers in immunology - 1 Jan 2026

Zhang Cong, Zhao Yanping, Pang Hui, Li Na, Zheng Haifang, Dong Jiahui, Liu Yanchao, Li Wuyun Tana, Li Hailing, Zhang Nan, Zhao Mengyu, Zhao Lingyan

Abstract excerpt

Background: To investigate the potential causal relationship between inflammatory cytokines and type 2 diabetes (T2D) using two-sample Mendelian randomization (MR) and to explore the transferability of inflammatory genetic susceptibility in a Mongolian population through polygenic score (PGS) analysis. Methods: A two-sample MR analysis was conducted using genome-wide association study (GWAS) summary statistics....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42488633
DOI: 10.3389/fimmu.2026.1848697
PMCID: PMC13388088

Genes

ARTN
CD5
CXCL10
CXCL9
PC
SLAMF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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