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Article

Causal Relationship and Shared Genetic Loci between Psoriasis and Type 2 Diabetes through Trans-Disease Meta-Analysis.

The Journal of investigative dermatology - 1 Jun 2021

Patrick Matthew T, Stuart Philip E, Zhang Haihan, Zhao Qingyuan, Yin Xianyong, He Kevin, Zhou Xu-Jie, Mehta Nehal N, Voorhees John J, Boehnke Michael, Gudjonsson Johann E, Nair Rajan P, Handelman Samuel K, Elder James T, Liu Dajiang J, Tsoi Lam C

Abstract excerpt

Psoriasis and type 2 diabetes (T2D) are complex conditions with significant impacts on health. Patients with psoriasis have a higher risk of T2D (∼1.5 OR) and vice versa, controlling for body mass index; yet, there has been a limited study comparing their genetic architecture. We hypothesized that there are shared genetic components between psoriasis and T2D. Trans-disease meta-analysis was applied to 8,016,731...

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Share to Body Mass Index
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to Genetic Loci

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to NF-kappa B

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Source

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Identifiers

PMID: 33385400
DOI: 10.1016/j.jid.2020.11.025
PMCID: PMC8154633

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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