Article

KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation

2023-03-08

Abstract excerpt

Immune cells sense the microenvironment to fine-tune their inflammatory responses. Patients with cryopyrin associated periodic syndrome (CAPS), caused by mutations in the NLRP3 gene, develop auto-inflammation triggered by non-antigenic, e.g. environmental cues. However, the underlying mechanisms are poorly understood. Here, we uncover that KCNN4, a calcium-activated potassium channel, links PIEZO-mediated mechano...

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Literature Corpus work: 3b315e0a-5cba-589c-a17e-a1130a85121e
DOI: 10.1101/2023.03.08.531717

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