SoMAS: Finding somatic mutations associated with alternative splicing in human cancers

Abstract excerpt

Aberrant alternative splicing is prevalent in cancer and affects most cancer hallmarks involving proliferation, angiogenesis, and invasion. Somatic point mutations can exert their cancer-driving functions via splicing disruption. We propose “SoMAS” ( So matic M utation associated with A lternative S plicing), an efficient computational pipeline based on principal component analysis techniques, to explore the r...

Topics

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• Alternative Splicing
• Gene Regulatory Networks
• Genetic Heterogeneity
• Internet
• Mutation
• Neoplasms
• Phenotype
• RNA Splicing

Identifiers and source

Literature Corpus work

909a0a93-873d-5812-8481-60aa29b7d2e7

DOI

10.1101/2023.07.06.547933