Article

Oxygen Nanocarrier Broke the Hypoxia Trap of Solid Tumors and Rescued Transfection Efficiency for Gene Therapy

2021-10-05

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Gene therapy shows great promise for a broad array of diseases. However, we found that hypoxic tumor microenvironment (TME) exerted significant inhibitory effects on transfection efficiency of a variety of gene vectors (such as Lipo 2000 and PEI) in an oxygen-dependent manner. Solid tumors inevitably resulted in acute hypoxic areas due to the rapid proliferation...

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Literature Corpus work: 90991177-de0f-5541-ab7f-89fe9cbc8037
DOI: 10.21203/rs.3.rs-951402/v1

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