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Oxygen nanobubbles revert hypoxia by methylation programming

18 Aug 2017

Abstract excerpt

Targeting the hypoxic tumor microenvironment has a broad impact in cancer epigenetics and therapeutics. Oxygen encapsulated nanosize carboxymethyl cellulosic nanobubbles were developed for mitigating the hypoxic regions of tumors to weaken the hypoxia-driven pathways and inhibit tumor growth. We show that 5-methylcytosine (5mC) hypomethylation in hypoxic regions of a tumor can be reverted to enhance cancer...

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PMID: 28839175
DOI: 10.1038/s41598-017-08988-7

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