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Article

Novel siRNA formulation to effectively knockdown mutant p53 in osteosarcoma.

PloS one - 1 Jan 2017

Kundu Anup K, Iyer Swathi V, Chandra Sruti, Adhikari Amit S, Iwakuma Tomoo, Mandal Tarun K

Abstract excerpt

OBJECTIVES: The tumor suppressor p53 plays a crucial role in the development of osteosarcoma. The primary objective of this study is to develop and optimize lipid based nanoparticle formulations that can carry siRNA and effectively silence mutant p53 in 318-1, a murine osteosarcoma cell line. METHODS: The nanoparticles were composed of a mixture of two lipids (cholesterol and DOTAP) and either PLGA or PLGA-PEG...

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Share to Bone Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28636657
DOI: 10.1371/journal.pone.0179168
PMCID: PMC5479560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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