Article
A sorting platform determines the order of protein secretion in bacterial type III systems.
Science (New York, N.Y.) - 4 Mar 2011
Lara-Tejero María, Kato Junya, Wagner Samuel, Liu Xiaoyun, Galán Jorge E
Abstract excerpt
Bacterial type III protein secretion systems deliver effector proteins into eukaryotic cells in order to modulate cellular processes. Central to the function of these protein-delivery machines is their ability to recognize and secrete substrates in a defined order. Here, we describe a mechanism by which a type III secretion system from the bacterial enteropathogen Salmonella enterica serovar Typhimurium can sort...
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