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Article

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

22 Jan 2019

Abstract excerpt

The circadian clock regulates immune responses to microbes and affects pathogen replication, but the underlying molecular mechanisms are not well understood. Here we demonstrate that the circadian components BMAL1 and REV-ERBα influence several steps in the hepatitis C virus (HCV) life cycle, including particle entry into hepatocytes and RNA genome replication. Genetic knock out of Bmal1 and over-expression or...

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PMID: 30670689
DOI: 10.1038/s41467-019-08299-7

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