Article
A model of the mammalian circadian oscillator including the REV-ERBalpha module.
Genome informatics. International Conference on Genome Informatics - 1 Jan 2004
Becker-Weimann Sabine, Wolf Jana, Kramer Achim, Herzel Hanspeter
Abstract excerpt
Many cellular and physiological processes have been shown to display a rhythm of about 24 hours. This so-called circadian rhythm is based on a system of interlocked negative and positive molecular feedback loops. Here we extend a previous model of the circadian oscillator by including REV-ERBalpha as an additional component. This new model will allow us to investigate the function of an additional negative...
Topics
- Animals
- Circadian Rhythm
- Cryptochromes
- DNA-Binding Proteins
- Feedback
- Flavoproteins
- Gene Deletion
- Mammals
- Models, Biological
- Models, Genetic
- Mutation