Article

In-silico functional prediction of novel tuberculosis pharmacogenetic variants and NAT2 phenotype prediction in African populations

2026-08-19

Abstract excerpt

Tuberculosis (TB) remains a major public health challenge, exerting profound socio-economic burdens and causing debilitating illness in approximately 2.5 million individuals across Africa annually. Optimized large-scale treatment regimens, such as NAT2 -genotype adjusted dosing, could improve patient outcomes and strengthen healthcare systems. However, fully addressing the complexity of multi-drug TB treatment re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9049a132-71f5-558f-a9d7-96c24b4ea077
DOI: 10.64898/2026.08.17.26360486

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

In-silico functional prediction of novel tuberculosis pharmacogenetic variants and NAT2 phenotype prediction in African populationsDOI 10.64898/2026.08.17.26360486Read

Characterization of NAT, GST, and CYP2E1 Genetic Variation in Sub-Saharan African Populations: Implications for Treatment of Tuberculosis and Other Diseases.Semantic proximity Read

Genetic Landscape of NAT2 in the Moroccan Population: Implications for Isoniazid Pharmacogenetics in Tuberculosis.Semantic proximity Read

Towards pharmacogenomics-guided tuberculosis (TB) therapy: N-acetyltransferase-2 genotypes among TB-infected Kenyans of mixed ethnicity.Semantic proximity Read

Pharmacogenetic Study of Drugs Affecting Mycobacterium tuberculosis.Semantic proximity Read

A Rapid Pharmacogenomic Assay to Detect NAT2 Polymorphisms and Guide Isoniazid Dosing for Tuberculosis Treatment.Semantic proximity Read

A rapid pharmacogenomic assay to detect <i>NAT2</i> polymorphisms and guide isoniazid dosing for tuberculosis treatmentSemantic proximity Read

A Nanopore Sequencing-based Pharmacogenomic Panel to Personalize Tuberculosis Drug Dosing.Semantic proximity Read

Genetic polymorphisms and adverse reactions to antituberculosis therapySemantic proximity Read

Pharmacogenomics and mutation informatics: correlation of NAT2 mutations and isoniazid acetylation rate.Semantic proximity Read

Novel variants of major drug-metabolising enzyme genes in diverse African populations and their predicted functional effects.Semantic proximity Read

Mapping the Pharmacogenetic Landscape in a Ugandan Population: Implications for Personalized Medicine in an Underrepresented Population.Semantic proximity Read

A Nanopore sequencing-based pharmacogenomic panel to personalize tuberculosis drug dosingSemantic proximity Read