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In Silico Genome Analysis Reveals the Evolution and Potential Impact of SARS-CoV-2 Omicron Structural Changes on Host Immune Evasion and Antiviral Therapeutics.

Viruses - 6 Nov 2022

Chauhan Dhruv, Chakravarty Nikhil, Jeyachandran Arjit Vijey, Jayakarunakaran Akshaya, Sinha Sanjeev, Mishra Rakesh, Arumugaswami Vaithilingaraja, Ramaiah Arunachalam

Abstract excerpt

New variants of SARS-CoV-2 continue to evolve. The novel SARS-CoV-2 variant of concern (VOC) B.1.1.529 (Omicron) was particularly menacing due to the presence of numerous consequential mutations. In this study, we reviewed about 12 million SARS-CoV-2 genomic and associated metadata using extensive bioinformatic approaches to understand how evolutionary and mutational changes affect Omicron variant properties....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36366559
DOI: 10.3390/v14112461
PMCID: PMC9697451

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