Article

NF2 Loss-of-Function and Hypoxia Drive Radiation Resistance in Grade 2 Meningiomas

2023-09-11

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> World Health Organization Grade 2 meningiomas (G2Ms) exhibit an aggressive natural history characterized by recurrence and therapy resistance. G2Ms with histopathological necrosis have been associated with worse local control (LC) following radiation therapy, but drivers and biomarkers of radiation resistance in these G2Ms remain unknown. <h4>Methods</h4> We performed genet...

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Literature Corpus work: 8fc21e46-e72c-5c05-9908-a561191a28d6
DOI: 10.1101/2023.09.08.556892

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