Loss of meningothelial identity and mesenchymal fate switching in NF2-mutant meningiomas.

doi:10.1007/s00401-026-03016-3

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Article

Loss of meningothelial identity and mesenchymal fate switching in NF2-mutant meningiomas.

Acta neuropathologica - 25 Apr 2026

Rahmanzade Ramin, Schweizer Leonille, Schmid Simone, Lausová Tereza, Sigismondo Gianluca, Esmaeili Benvidi Mozhgan, Patel Rushda, Kaan Aras Fuat, Banan Rouzbeh, Reuss David, Jäger Natalie, Forster Marie-Theresa, Zeller Viktoria, Kohlhof-Meinecke Patricia, Fisseler-Eckhoff Annette, Carl Barbara, Harter Patrick N, Lamszus Katrin, Schüller Ulrich, Zapotocky Michal, Acker Till, Hanemann C O, Schittenhelm Jens, Brack Eva, Flucke Uta, Mechtersheimer Gunhild, Bertero Luca, Haberler Christine, Capper David, von Deimling Andreas, Sievers Philipp, Sahm Felix

Abstract excerpt

Intracranial sarcomas can arise secondarily from primary brain tumors, including gliomas and meningiomas, either spontaneously or following radiotherapy. The current WHO classification recognizes sarcomatous transformation in several tumor entities; however, sarcomas arising from meningiomas remain poorly characterized and are regarded as a possible histological manifestation within the spectrum of anaplastic...

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Identifiers

PMID: 42034799
DOI: 10.1007/s00401-026-03016-3
PMCID: PMC13110230

Genes

NF2
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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