Article

Domain Binding and Isotype Dictate the Activity of Anti-human OX40 Antibodies

2020-06-29

Abstract excerpt

Previous data suggests that anti-OX40 mAb can elicit anti-tumour effects in mice through deletion of Tregs. However, OX40 also has powerful costimulatory effects on T cells which could evoke therapeutic responses. The contributions of these different effector mechanisms has not previously been systematically evaluated, particularly for mAb directed to human OX40. Therefore, we generated a novel human OX40 knock-in...

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Literature Corpus work: 8f7edbfb-461f-533e-9a49-86acce88cf72
DOI: 10.1101/2020.06.29.177691

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