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Advancing In Vivo Detection of T-Cell Function: Development and Preclinical Evaluation of 89 Zr-Ivuxolimab, a Human OX40 PET Tracer

24 Jul 2025

Abstract excerpt

The variable response to cancer immunotherapies highlights a critical gap in our ability to predict and monitor treatment efficacy. To address this, there is an urgent clinical need for advanced molecular imaging technologies that can noninvasively and precisely assess whole-body immune responses. The OX40 receptor (CD134), a potent costimulatory molecule on T cells, serves as a highly specific marker of T-cell...

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PMID: 40707142
DOI: 10.2967/jnumed.125.269799

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