Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels.

Abstract excerpt

Piezo proteins have been proposed as the long-sought-after mechanosensitive cation channels in mammals that play critical roles in various mechanotransduction processes. However, the molecular bases that underlie their ion permeation and mechanotransduction have remained functionally undefined. Here we report our finding of the miniature pore-forming module of Piezo1 that resembles the pore architecture of other...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Acid Sensing Ion Channels
• Share to Calcium Chloride