Article
Unraveling the phenotypic states of human innate-like T cells: Comparative insights with conventional T cells and mouse models.
Cell reports - 24 Sept 2024
Loh Liyen, Carcy Salomé, Krovi Harsha S, Domenico Joanne, Spengler Andrea, Lin Yong, Torres Joshua, Prabakar Rishvanth K, Palmer William, Norman Paul J, Stone Matthew, Brunetti Tonya, Meyer Hannah V, Gapin Laurent
Abstract excerpt
The "innate-like" T cell compartment, known as Tinn, represents a diverse group of T cells that straddle the boundary between innate and adaptive immunity. We explore the transcriptional landscape of Tinn compared to conventional T cells (Tconv) in the human thymus and blood using single-cell RNA sequencing (scRNA-seq) and flow cytometry. In human blood, the majority of Tinn cells share an effector program driven...
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