Article

Metabolic resistance of Aβ3pE-42, target epitope of the anti-Alzheimer therapeutic antibody, donanemab

2024-01-31

Abstract excerpt

The amyloid β peptide (Aβ) starting with pyroglutamate (pE) at position 3 and ending at position 42 (Aβ3pE-42) is a dominant species that accumulates in the Alzheimer’s disease (AD) brain. Consistently, a therapeutic antibody raised against this species, donanemab, has been shown to be effective in recent clinical trials. While the primary Aβ species produced physiologically is Aβ1-40/42, an explanation for how an...

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Literature Corpus work: 8ed6c96c-f306-50e1-8eed-0a2e9eb27deb
DOI: 10.1101/2024.01.30.578111

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