Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.

doi:10.1523/JNEUROSCI.1794-11.2011

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Article

Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Sept 2011

Alexandru Anca, Jagla Wolfgang, Graubner Sigrid, Becker Andreas, Bäuscher Christoph, Kohlmann Stephanie, Sedlmeier Reinhard, Raber Kerstin A, Cynis Holger, Rönicke Raik, Reymann Klaus G, Petrasch-Parwez Elisabeth, Hartlage-Rübsamen Maike, Waniek Alexander, Rossner Steffen, Schilling Stephan, Osmand Alexander P, Demuth Hans-Ulrich, von Hörsten Stephan

Abstract excerpt

Posttranslational amyloid-β (Aβ) modification is considered to play an important role in Alzheimer's disease (AD) etiology. An N-terminally modified Aβ species, pyroglutamate-amyloid-β (pE3-Aβ), has been described as a major constituent of Aβ deposits specific to human AD but absent in normal aging. Formed via cyclization of truncated Aβ species by glutaminyl cyclase (QC; QPCT) and/or its isoenzyme (isoQC;...

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Identifiers

PMID: 21900558
DOI: 10.1523/JNEUROSCI.1794-11.2011
PMCID: PMC6623394

Genes

QPCT
QPCTL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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