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Article

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jan 2010

Wirths Oliver, Bethge Tobias, Marcello Andrea, Harmeier Anja, Jawhar Sadim, Lucassen Paul J, Multhaup Gerd, Brody David L, Esparza Thomas, Ingelsson Martin, Kalimo Hannu, Lannfelt Lars, Bayer Thomas A

Abstract excerpt

The presence of Abeta(pE3) (N-terminal truncated Abeta starting with pyroglutamate) in Alzheimer's disease (AD) has received considerable attention since the discovery that this peptide represents a dominant fraction of Abeta peptides in senile plaques of AD brains. This was later confirmed by other reports investigating AD and Down's syndrome postmortem brain tissue. Importantly, Abeta(pE3) has a higher...

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Identifiers

PMID: 19823761
DOI: 10.1007/s00702-009-0314-x
PMCID: PMC2789212

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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