Article

Identification of a novel Aβ(pGlu3-x) targeting pathway in Alzheimer’s disease

2026-03-03

Abstract excerpt

<title>Abstract</title> <p> The pyroglutamate-3-modified form of the amyloid-β (Aβ) peptide (Aβ(pGlu3-x)) is enriched in brains of Alzheimer’s disease (AD) patients and is highly neurotoxic, aggregation-prone, resistant to proteolytic degradation and acts as a seed for the co-aggregation of unmodified Aβ. Therefore, it became a pharmacologic target for AD therapy either by inhibition of its synthesizing enzyme,...

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Literature Corpus work: 905d8924-f629-5db6-a3aa-91896c6e3e68
DOI: 10.21203/rs.3.rs-8850276/v1

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