Back to search

Article

Heterospecific developmental models highlight the role of <i>FBXO32</i> in neural crest lineages and the significance of its variant in pediatric melanoma

2023-03-12

Abstract excerpt

<h4>ABSTRACT</h4> Melanoma is a rare sporadic pediatric cancer caused by de novo genetic accidents. To analyze the involvement of FBXO32 of unknown biological significance, we set up original developmental in vivo , ex vivo , and in vitro models to unmask the biological role of FBXO32 in cephalic and trunk neural crest lineages. We show that FBXO32 silencing impairs melanocyte proliferation, differentiatio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8ed6c949-291d-5660-86ef-2d13631f5d06
DOI
10.1101/2023.03.10.532100
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Heterospecific developmental models highlight the role of <i>FBXO32</i> in neural crest lineages and the significance of its variant in pediatric melanomaDOI 10.1101/2023.03.10.532100
Mosaicism in Cutaneous Disorders.Semantic proximity
Mosaicism in genodermatoses.Semantic proximity
Generation of Schwann cell derived melanocytes from hPSCs identifies pro-metastatic factors in melanomaSemantic proximity
Spatially resolved diversity in molecular states underlies congenital melanocytic nevi and associated tumorsSemantic proximity
Identification and Validation of Key Genes in Giant Congenital Melanocytic Nevi by RNA Sequencing AnalysisSemantic proximity
Congenital malignant melanoma: An Integrated Clinicopathological Clinical Case SeriesSemantic proximity
Inherited duplications of <i>PPP2R3B</i> promote naevi and melanoma via a novel <i>C21orf91</i> -driven proliferative phenotypeSemantic proximity
Melanomas and Mesenchymal Tumors Arising in Giant Congenital Melanocytic Nevi: Clinico-Pathological and Molecular Characterization of a Case Series.Semantic proximity
GNAQ Induces Melanomagenesis in Mitfa-Independent Melanocyte Progenitors in a Zebrafish Model of Uveal MelanomaSemantic proximity
Transcriptomic analysis of giant congenital melanocytic nevi across different anatomic sitesSemantic proximity
Developmental pathways activated in melanocytes and melanoma.Semantic proximity
Identifying <i>in vivo</i> genetic dependencies of melanocyte and melanoma developmentSemantic proximity
Select a neighboring publication to make it the new centre.