Article

Inherited duplications of <i>PPP2R3B</i> promote naevi and melanoma via a novel <i>C21orf91</i> -driven proliferative phenotype

2019-06-15

Abstract excerpt

The majority of the heredity of melanoma remains unexplained, however inherited copy number changes have not yet been systematically studied. The genetic environment is highly relevant to treatment stratification, and new gene discovery is therefore desirable. Using an unbiased whole genome screening approach for copy number we identify here a novel melanoma predisposing factor, familial duplications of gene PPP2...

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Literature Corpus work: 2b29b2e3-cc22-541c-92eb-e99ef4926228
DOI: 10.1101/672576

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