Article
Melanomas and Mesenchymal Tumors Arising in Giant Congenital Melanocytic Nevi: Clinico-Pathological and Molecular Characterization of a Case Series.
Pigment cell & melanoma research - 1 Jan 2026
Rossi Sabrina, Barresi Sabina, Giovannoni Isabella, Genovese Silvia, Costabile Valentino, Stracuzzi Alessandra, Vallese Silvia, Tancredi Chantal, Diociaiuti Andrea, Milano Giuseppe M, Ferrari Andrea, Bertolini Patrizia, Chiaravalli Stefano, Agolini Emanuele, D'Elia Gemma, Catino Giorgia, Martucci Licia, Cajozzo Marta, Dell'Otto Fabio, Bisogno Gianni, Crocoli Alessandro, Miele Evelina, Zambruno Giovanna, De Pasquale Maria Debora, Zama Mario, Novelli Antonio, El Hachem May, Alesi Viola, Alaggio Rita
Abstract excerpt
Giant congenital melanocytic nevi (GCMN) are benign mosaic disorders that may give rise to various tumor types through incompletely understood mechanisms. We characterized a series of two melanomas and four mesenchymal tumors (two embryonal rhabdomyosarcomas, one small round cell sarcoma, one low-grade mesenchymal tumor) arising in GCMN. Median onset age was 3.5 years and 3 months for melanoma and mesenchymal...
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