Article

Detecting Extrachromosomal DNA from Routine Histopathology

2026-03-02

Abstract excerpt

Extrachromosomal DNA (ecDNA) is a major driver of oncogene amplification, tumour heterogeneity and poor clinical outcomes [1–3], yet its detection relies on specialised genomic assays that are not integrated into routine diagnostics. Here, we show that ecDNA status can be inferred directly from standard haematoxylin and eosin–stained whole-slide pathology images. We develop an end-to-end, weakly supervised deep le...

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Literature Corpus work: 9bbcdc7b-f006-5601-af97-e0a2190bfb48
DOI: 10.64898/2026.02.27.708546

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