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Article

Increased flexibility of the SARS-CoV-2 RNA-binding site causes resistance to remdesivir

27 Mar 2023

Abstract excerpt

Mutations continue to accumulate within the SARS-CoV-2 genome, and the ongoing epidemic has shown no signs of ending. It is critical to predict problematic mutations that may arise in clinical environments and assess their properties in advance to quickly implement countermeasures against future variant infections. In this study, we identified mutations resistant to remdesivir, which is widely administered to...

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PMID: 36972312
DOI: 10.1371/journal.ppat.1011231

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