Article

Studies within fragment-based drug discovery : library synthesis and hit-to-lead optimisation

2020-01-01

Abstract excerpt

This thesis reports two projects aimed at addressing challenges within fragment-based drug discovery. The first project describes efforts towards utilising synthetic methodology to address deficiencies within fragment screening collections. This involved the development of a modular, robust and scalable route to access α,α-disubstituted amino ester building blocks, which in turn were derivatised to allow the rapid...

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Identifiers and source

Literature Corpus work: 8eb75c68-882b-5e59-ae75-4fb0607a6b45
DOI: 10.17863/cam.63171

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