Article

Catestatin regulates the colonic mucus layer in inflammatory bowel disease

2021-02-10

Abstract excerpt

<h4>Background</h4> The pro-hormone chromogranin A (CgA) and its bioactive cleavage product catestatin (CST) are both associated with inflammatory bowel disease (IBD) and dysregulated barrier functions, but their exact role has remained elusive. Here, we demonstrate that CST regulates the colonic mucus layer. <h4>Methods</h4> CST levels were measured in feces of IBD patients. The mucus layer, goblet cells, and i...

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Literature Corpus work: 8e90f767-210b-5e54-9909-56f39d856460
DOI: 10.1101/2021.02.09.430377

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