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Article

Retinoic acid synthesis by a population of choroidal stromal cells

19 Sept 2020

Abstract excerpt

Choroidal all- trans -retinoic acid (atRA) may play a key role in the control of postnatal eye growth in a variety of vertebrates through modulation of scleral extracellular matrix synthesis and may therefore play a crucial role in the development of myopia. In the chick eye, choroidal atRA synthesis is exclusively regulated by its synthesizing enzyme, retinaldehyde dehydrogenase 2 (RALDH2). In chicks and humans,...

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PMID: 32961175
DOI: 10.1016/j.exer.2020.108252

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