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Article

Retinoic acid signaling regulates spatiotemporal specification of human green and red cones

11 Jan 2024

Abstract excerpt

Trichromacy is unique to primates among placental mammals, enabled by blue (short/S), green (medium/M), and red (long/L) cones. In humans, great apes, and Old World monkeys, cones make a poorly understood choice between M and L cone subtype fates. To determine mechanisms specifying M and L cones, we developed an approach to visualize expression of the highly similar M- and L-opsin mRNAs. M-opsin was observed...

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PMID: 38206904
DOI: 10.1371/journal.pbio.3002464

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