Article

<i>Opa1</i> overexpression protects from early onset <i>Mpv17</i> <sup> <i>-/-</i> </sup> -related mouse kidney disease

2020-03-18

Abstract excerpt

Moderate overexpression of Opa1 , encoding a master regulator of mitochondrial cristae morphology, has been shown to improve significantly mitochondrial damage induced by drugs, surgical denervation, or genetically determined OXPHOS defects. However, this approach has been so far demonstrated in a limited number of genetically defective OXPHOS models characterized by specific impairment of a single mitochondrial...

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Literature Corpus work: 8e78cb8f-92ae-5b8f-8954-dceaabc76514
DOI: 10.1101/2020.03.18.996561

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