Article
Functional rescue of the glomerulosclerosis phenotype in Mpv17 mice by transgenesis with the human Mpv17 homologue.
Kidney international - 1 Jul 1995
Schenkel J, Zwacka R M, Rutenberg C, Reuter A, Waldherr R, Weiher H
Abstract excerpt
The germ line insertion of a defective retrovirus into the Mpv17 gene of mice is associated with a recessive phenotype. Mice homozygous for the integration develop glomerulosclerosis at a young age. The phenotype resembles human glomerulosclerosis in its physiological parameters as well as in histology. A human homologue of the Mpv17 gene has been identified, isolated and analyzed. We here show that this gene,...
Topics
- Animals
- Base Sequence
- Cloning, Molecular
- Disease Models, Animal
- Gene Expression
- Genetic Vectors
- Glomerulonephritis
- Humans
- Mice
- Mice, Transgenic
- Molecular Sequence Data