Article
Inner ear defect similar to Alport's syndrome in the glomerulosclerosis mouse model Mpv17.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery - 1 Jan 1996
Meyer zum Gottesberge A M, Reuter A, Weiher H
Abstract excerpt
The Mpv17 mouse strain is a recessive transgenic mouse mutant that develops glomerulosclerosis and nephrotic syndrome at a young age. The phenotype results from a loss of function of a gene coding for a hydrophobic peroxisomal protein of 176 amino acids of 20 kDa following its destruction by retr...
Topics
- Animals
- Disease Models, Animal
- Ear, Inner
- Female
- Glomerulosclerosis, Focal Segmental
- Kidney
- Male
- Mice
- Mice, Transgenic
- Microscopy, Electron
- Nephritis, Hereditary
- Organ of Corti
- Phenotype