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Article

KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination.

eLife - 9 Aug 2017

Ramirez-Martinez Andres, Cenik Bercin Kutluk, Bezprozvannaya Svetlana, Chen Beibei, Bassel-Duby Rhonda, Liu Ning, Olson Eric N

Abstract excerpt

Maintenance of muscle function requires assembly of contractile proteins into highly organized sarcomeres. Mutations in Kelch-like protein 41 (KLHL41) cause nemaline myopathy, a fatal muscle disorder associated with sarcomere disarray. We generated KLHL41 mutant mice, which display lethal disruption of sarcomeres and aberrant expression of muscle structural and contractile proteins, mimicking the hallmarks of the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28826497
DOI: 10.7554/eLife.26439
PMCID: PMC5589419

Genes

KLHL41

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination.PMID 28826497Read ↗

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Dysregulation of NRAP degradation by KLHL41 contributes to pathophysiology in nemaline myopathySemantic proximity Read ↗

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KLHL41 orchestrates sarcomere assembly and size to drive skeletal muscle hypertrophy <i>in vivo</i>Semantic proximity Read ↗

Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onsetSemantic proximity Read ↗

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