Article

Mitigating Pathogenesis for Target Discovery and Disease Subtyping

2023-08-16

Abstract excerpt

Treatments ideally mitigate pathogenesis, or the detrimental effects of the root causes of disease. However, existing definitions of treatment effect fail to account for pathogenic mechanism. We therefore introduce the Treated Root causal Effects (TRE) metric which measures the ability of a treatment to modify root causal effects. We leverage TREs to automatically identify treatment targets and cluster patients wh...

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Literature Corpus work: 8e38b4d3-2bc6-5ea2-a02f-0121051297db
DOI: 10.1101/2023.08.12.23294026

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