Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human cone photoreceptor dependence on RPE65 isomerase

11 Sept 2007

Abstract excerpt

The visual (retinoid) cycle, the enzymatic pathway that regenerates chromophore after light absorption, is located primarily in the retinal pigment epithelium (RPE) and is essential for rod photoreceptor survival. Whether this pathway also is essential for cone photoreceptor survival is unknown, and there are no data from man or monkey to address this question. The visual cycle is naturally disrupted in humans...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Photoreceptor and optogenetics research
Share to Retinal Development and Disorders
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17848510
DOI: 10.1073/pnas.0706367104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human cone photoreceptor dependence on RPE65 isomerasePMID 17848510Read ↗

Retinal disease in Rpe65-deficient mice: comparison to human leber congenital amaurosis due to RPE65 mutations.Semantic proximity Read ↗

Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success.Semantic proximity Read ↗

<i>RPE65</i> knockout <i>Xenopus laevis</i> have a compromised but detectable electroretinogram and altered visual responses, without retinal degeneration or altered melanophore dispersionSemantic proximity Read ↗

Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium.Semantic proximity Read ↗

A History of the Classical Visual Cycle.Semantic proximity Read ↗

Defining the residual vision in leber congenital amaurosis caused by RPE65 mutations.Semantic proximity Read ↗

Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.Semantic proximity Read ↗

Crystal structure of native RPE65, the retinoid isomerase of the visual cycle.Semantic proximity Read ↗

Leber congenital amaurosis due to RPE65 mutations and its treatment with gene therapy.Semantic proximity Read ↗

In conditions of limited chromophore supply rods entrap 11-cis-retinal leading to loss of cone function and cell death.Semantic proximity Read ↗

Nature of the visual loss in observers with Leber's congenital amaurosis caused by specific mutations in RPE65.Semantic proximity Read ↗

Pathways and disease-causing alterations in visual chromophore production for vertebrate visionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.