Expanding primary cells from mucoepidermoid and other salivary gland neoplasms for genetic and chemosensitivity testing

Abstract excerpt

Restricted availability of cell and animal models is a rate-limiting step for investigation of salivary gland neoplasm pathophysiology and therapeutic response. Conditionally reprogrammed cell (CRC) technology enables establishment of primary epithelial cell cultures from patient material. This study tested a translational workflow for acquisition, expansion and testing of CRC-derived primary cultures of salivary...

Topics

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• Disease Models, Animal
• Exome Sequencing
• Organoids
• Phenotype
• Salivary Gland Neoplasms
• Salivary Gland Tumors Diagnosis and Treatment
• Transplantation, Heterologous
• Xenograft Model Antitumor Assays

Identifiers and source

Literature Corpus work

8e293b6f-b766-5781-b3a0-627681089d36

DOI

10.1101/171652