Novel Preclinical Human Salivary Gland Cancer Models Established Using Organoid Culture And Patient-Derived Xenografting

Abstract excerpt

<title>Abstract</title> <p>Salivary gland carcinoma (SGC) has poor prognosis depending on the histological subtype. However, due to the scarcity of preclinical experimental models, its pathogenesis remains largely unknown, hampering the development of new treatment modalities for patients with these malignancies. Here, we first report the establishment of a large collection of human SGC experimental models for mu...

Topics

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• Disease Models, Animal
• Ear and Head Tumors
• Organoids
• Phenotype
• Salivary Gland Neoplasms
• Salivary Gland Tumors Diagnosis and Treatment
• Transplantation, Heterologous
• Xenograft Model Antitumor Assays

Identifiers and source

Literature Corpus work

8c38b973-cd18-5369-876b-57774f9073e7

DOI

10.21203/rs.3.rs-779030/v1