Article
Establishment of experimental salivary gland cancer models using organoid culture and patient-derived xenografting.
Cellular oncology (Dordrecht, Netherlands) - 1 Apr 2023
Aizawa Yoshihiro, Takada Kentaro, Aoyama Jun, Sano Daisuke, Yamanaka Shoji, Seki Masahide, Kuze Yuta, Ramilowski Jordan A, Okuda Ryo, Ueno Yasuharu, Nojima Yusuke, Inayama Yoshiaki, Hatakeyama Hiromitsu, Hatano Takashi, Takahashi Hideaki, Nishimura Goshi, Fujii Satoshi, Suzuki Yutaka, Taniguchi Hideki, Oridate Nobuhiko
Abstract excerpt
PURPOSE: Depending on its histological subtype, salivary gland carcinoma (SGC) may have a poor prognosis. Due to the scarcity of preclinical experimental models, its molecular biology has so far remained largely unknown, hampering the development of new treatment modalities for patients with these malignancies. The aim of this study was to generate experimental human SGC models of multiple histological subtypes...
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