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Article

Mechanism of Viral Glycoprotein Targeting by Membrane-Associated RING-CH Proteins.

mBio - 16 Mar 2021

Lun Cheng Man, Waheed Abdul A, Majadly Ahlam, Powell Nicole, Freed Eric O

Abstract excerpt

An emerging class of cellular inhibitory proteins has been identified that targets viral glycoproteins. These include the membrane-associated RING-CH (MARCH) family of E3 ubiquitin ligases that, among other functions, downregulate cell surface proteins involved in adaptive immunity. The RING-CH domain of MARCH proteins is thought to function by catalyzing the ubiquitination of the cytoplasmic tails (CTs) of...

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Identifiers

PMID: 33727347
DOI: 10.1128/mBio.00219-21
PMCID: PMC8092221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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