ADP heptose, a novel pathogen‐associated molecular pattern identified in Helicobacter pylori

Abstract excerpt

ABSTRACT The gastric pathogen Helicobacter pylori activates the NF‐κB pathway in human epithelial cells via the recently discovered α‐kinase 1 TRAF‐interacting protein with forkhead‐associated domain (TIFA) axis. We and others showed that this pathway can be triggered by heptose 1,7‐bisphosphate (HBP), an LPS intermediate produced in gram‐negative bacteria that represents a new pathogen‐associated molecular...

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