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Article

The ALPK1 pathway drives the inflammatory response to Campylobacter jejuni in human intestinal epithelial cells

2 Aug 2021

Abstract excerpt

The Gram-negative bacterium Campylobacter jejuni is a major cause of foodborne disease in humans. After infection, C. jejuni rapidly colonizes the mucus layer of the small and large intestine and induces a potent pro-inflammatory response characterized by the production of a large repertoire of cytokines, chemokines, and innate effector molecules, resulting in (bloody) diarrhea. The virulence mechanisms by which...

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PMID: 34339468
DOI: 10.1371/journal.ppat.1009787

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