Back to search

Article

<i>Helicobacter pylori</i> modulates heptose metabolite biosynthesis and heptose-dependent innate immune host cell activation by multiple mechanisms

2023-03-17

Abstract excerpt

Heptose metabolites including ADP-heptose are involved in bacterial lipopolysaccharide and cell envelope biosynthesis. Recently, heptoses were also identified to have potent pro-inflammatory activity on human cells as novel microbe-associated molecular patterns. The gastric pathogenic bacterium Helicobacter pylori produces heptose metabolites which it transports into human cells through its Cag type 4 secretion s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
578742d2-5699-5498-ad95-c79df3c7dcc3
DOI
10.1101/2023.03.17.531716
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
<i>Helicobacter pylori</i> modulates heptose metabolite biosynthesis and heptose-dependent innate immune host cell activation by multiple mechanismsDOI 10.1101/2023.03.17.531716
ADP heptose, a novel pathogen-associated molecular pattern associated with <i>Helicobacter pylori</i> type 4 secretionSemantic proximity
ADP-heptose attenuates Helicobacter pylori -induced dendritic cell activationSemantic proximity
Helicobacter pylori GmhB enzyme involved in ADP-heptose biosynthesis pathway is essential for lipopolysaccharide biosynthesis and bacterial virulenceSemantic proximity
ADP heptose, a novel pathogen‐associated molecular pattern identified in Helicobacter pyloriSemantic proximity
ADP‐heptose enables Helicobacter pylori to exploit macrophages as a survival niche by suppressing antigen‐presenting HLA‐II expressionSemantic proximity
A Bittersweet Kiss of Gram-Negative Bacteria: The Role of ADP-Heptose in the Pathogenesis of InfectionSemantic proximity
Identification of a D-glycero-D-manno-heptosyltransferase gene from Helicobacter pylori.Semantic proximity
Metabolic labelling of cholesteryl glucosides in Helicobacter pylori reveals how the uptake of human lipids enhances bacterial virulenceSemantic proximity
Niche-specific metabolic signatures in non-typeable <i>Haemophilus influenzae</i>Semantic proximity
Expanded metabolic reconstruction of Helicobacter pylori (iIT341 GSM/GPR): an in silico genome-scale characterization of single- and double-deletion mutants.Semantic proximity
Advances in Helicobacter pylori lipopolysaccharide structure and functionSemantic proximity
Roles of Lipopolysaccharide Glycosyltransferases in Maintenance of <i>Helicobacter pylori</i> Morphology, Cell Wall Permeability, and Antimicrobial SusceptibilitiesSemantic proximity
Select a neighboring publication to make it the new centre.