Article

Transcriptomic Architecture of Type 2 Diabetes in Human Pancreatic Islets: An Integrative Meta-Analysis and Machine Learning Framework for Biomarker Discovery

2026-06-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Type 2 diabetes mellitus (T2D) is defined by progressive pancreatic β-cell dysfunction whose molecular underpinnings remain incompletely understood. Single-cohort transcriptomic analyses of donor islets have yielded heterogeneous gene lists of limited cross-study reproducibility, constraining both mechanistic interpretation and biomarker development. <h4>Methods</h4> We com...

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Literature Corpus work: ab7045b7-83c5-5a69-b633-da674a07be14
DOI: 10.64898/2026.06.08.26355184

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