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Article

Aging: Somatic Mutations, Epigenetic Drift and Gene Dosage Imbalance.

Trends in cell biology - 1 Apr 2017

Veitia Reiner A, Govindaraju Diddahally R, Bottani Samuel, Birchler James A

Abstract excerpt

Aging involves a progressive decline of metabolic function and an increased incidence of late-onset degenerative disorders and cancer. To a large extent, these processes are influenced by alterations affecting the integrity of genome architecture and, ultimately, its phenotypic expression. Despite the progress made towards establishing causal links between genomic and epigenomic changes and aging, mechanisms...

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PMID: 27939088
DOI: 10.1016/j.tcb.2016.11.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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