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Article

Subunit interactions of the disease-related hexameric GlcNAc-1-phosphotransferase complex.

Human molecular genetics - 1 Dec 2015

De Pace Raffaella, Velho Renata Voltolini, Encarnação Marisa, Marschner Katrin, Braulke Thomas, Pohl Sandra

Abstract excerpt

The multimeric GlcNAc-1-phosphotransferase complex catalyzes the formation of mannose 6-phosphate recognition marker on lysosomal enzymes required for receptor-mediated targeting to lysosomes. GNPTAB and GNPTG encode the α/β-subunit precursor membrane proteins and the soluble γ-subunits, respectively. Performing extensive mutational analysis, we identified the binding regions of γ-subunits in a previously...

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Share to Amino Acid Motifs
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26385638
DOI: 10.1093/hmg/ddv387

Genes

GNPTG
GNPTAB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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