Article

Multi-omic screening of invasive GBM cells in engineered biomaterials and patient biopsies reveals targetable transsulfuration pathway alterations

2023-02-24

Abstract excerpt

<h4>ABSTRACT</h4> While the poor prognosis of glioblastoma arises from the invasion of a subset of tumor cells, little is known of the metabolic alterations within these cells that fuel invasion. We integrated spatially addressable hydrogel biomaterial platforms, patient site-directed biopsies, and multi-omics analyses to define metabolic drivers of invasive glioblastoma cells. Metabolomics and lipidomics reveale...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8dabd0d9-6461-5543-bcfd-985cb2367808
DOI: 10.1101/2023.02.23.529575

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-omic screening of invasive GBM cells in engineered biomaterials and patient biopsies reveals targetable transsulfuration pathway alterationsDOI 10.1101/2023.02.23.529575Read

Human glioblastoma cell motility depends on the activity of the cysteine metabolism enzyme 3-Mercaptopyruvate sulfurtransferaseSemantic proximity Read

Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactionsSemantic proximity Read

Hyaluronidase isoforms can promote or suppress glioma invasion within 3D Hyaluronic Acid MatricesSemantic proximity Read

Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide productionSemantic proximity Read

Crosstalk between microglia and patient-derived glioblastoma cells inhibit invasion in a three-dimensional gelatin hydrogel modelSemantic proximity Read

Metabolic-imaging of human glioblastoma live tumors: a new precision-medicine approach to predict tumor treatment response earlySemantic proximity Read

Methylthioadenosine is Not Dramatically Elevated in <i>MTAP</i> -Homozygous Deleted Primary GlioblastomasSemantic proximity Read

Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor nichesSemantic proximity Read

Multifunctional Hydrogel with Mild Photothermal Properties Enhances Diabetic Wound Repair by Targeting MRSA Energy MetabolismSemantic proximity Read

Oncometabolite R-2 hydroxyglutarate aids the inflammatory transformation of peritumoral astrocytesSemantic proximity Read

Mesenchymal-like glioma cells are enriched in the gelatin methacrylate hydrogelsSemantic proximity Read

Expanding Microgel Parameters to Model the Tumor Microenvironment and Examine Temozolomide Resistance in GlioblastomaSemantic proximity Read