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Article

Cognitive and Motor Dysfunction in STXBP1 R406H Mice.

Journal of molecular neuroscience : MN - 28 Feb 2026

Liu Hua, Duan Ya-Ze, Li Shang, Hu Yi, Mao Xiao, Cheng Yong

Abstract excerpt

The STXBP1 protein critically regulates synaptic vesicle fusion and neurotransmitter release, with its mutations implicated in neurodevelopmental disorders. STXBP1 R406H can lead to the occurrence of early-onset epileptic encephalopathy (EOEE). To better elucidate the molecular mechanisms underlying pathogenesis，we generated an STXBP1 R406H mutation mouse model that recapitulated key cognitive-social deficits...

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PMID: 41762326
DOI: 10.1007/s12031-026-02480-6

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STXBP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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