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Article

Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells.

Journal of virology - 1 Dec 2008

Sinigalia Elisa, Alvisi Gualtiero, Mercorelli Beatrice, Coen Donald M, Pari Gregory S, Jans David A, Ripalti Alessandro, Palù Giorgio, Loregian Arianna

Abstract excerpt

The presumed processivity subunit of human cytomegalovirus (HCMV) DNA polymerase, UL44, forms homodimers. The dimerization of UL44 is important for binding to DNA in vitro; however, whether it is also important for DNA replication in a cellular context is unknown. Here we show that UL44 point mutants that are impaired for dimerization, but not for nuclear localization or interaction with the C terminus of the...

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Identifiers

PMID: 18842734
DOI: 10.1128/JVI.01193-08
PMCID: PMC2593364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells.PMID 18842734Read ↗

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